BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Byrne has demonstrated that although subjects can make deductively valid inferences of the modus ponens and modus tollens forms, these valid inferences can be suppressed by presenting an appropriate additional premise “If R then Q” with the original conditional “If P then Q”. This suppression effect challenges the assumption of all syntactic theories of conditional reasoning that formal rules of inference such as modus ponens is part of mental logic. This paper argues that both the syntactic and the mental model (...) accounts of the suppression effect are inadequate because they fail to give a principled account of the critical interpretive component involved in reasoning. In contrast, the relative salience model proposed in this study emphasized the centrality of the interpretative processes with the critical component being the relative salience of premises as judged by subjects on the basis of their prior knowledge activated in particular problem situations. Using 120 undergraduates and 120 policemen as subjects, predictions from the model were tested and confirmed in a suppression paradigm and evidence of convergent validity for the construct of salience were obtained. The results cannot be reconciled with either the syntactic view or the mental model view that have dominated theories of conditional reasoning. (shrink)

Dialogial inquiry is proposed to second grade students in this project, and dialogue, that examines the philosophy of the human body.

Study on Islamic ethics and religious life in view of Islamic doctrines.

In The Market Experience, Robert Lane restates the central criticism of economic views of human satisfaction?namely, that they define welfare as utility and, in practice if not in theory, use money as the measure of utility, while in reality utility (or welfare) ought to be defined as happiness. In exploring the implications of this noneconomic definition for our assessment of markets, Lane summarizes the evidence about how people assess their own happiness more successfully than he clarifies the meaning of that (...) word. Since increases in income above a certain minimum do not increase happiness, work must be made more meaningful. (shrink)

The civil rights, antiwar, and student upheavals of our day have served, aside from their primary objectives, to reawaken our consciousness of the basic problems of ethical and political obligation.

Various aspects of semantic features drive early vocabulary development, but less is known about how the global and local structure of the overall semantic feature space influences language acquisition. A feature network of English words was constructed from a large database of adult feature production norms such that edges in the network represented feature distances between words (i.e., Manhattan distances of probability distributions of features elicited for each pair of words). A word's global feature distinctiveness is measured with respect to (...) all other words in the network and a word's local feature distinctiveness is measured relative to words in sub‐networks derived from clustering analyses. This paper investigates how feature distinctiveness of individual words at local and global scales of the network influences language acquisition. Regression analyses indicate that global feature distinctiveness was associated with earlier age of acquisition ratings, and was a stronger predictor of age of acquisition than local feature distinctiveness. These results suggest that the global structure of the semantic feature network could play an important role in language acquisition, whereby globally distinctive concepts help to structure vocabulary development over the lifespan. (shrink)

This paper argues that many of our most important theories of retributivism are unwittingly committed to the radical thesis that prepunishment—punishment before an offense—is morally permissible. From the perspective of diachronic justice on which these theories crucially depend, the timing of retribution is, ceteris paribus, irrelevant. But retributivism’s counterintuitive support does not stop there: there are conditions under which pre-offense apprehension and punishment guarantees a higher probability of justice being done. Under these conditions, the popular retributive theories I have in (...) mind do not just permit, but require, prepunishment. (shrink)

This book offers for the first time a complete scholarly translation, commentary, and glossary in a modern European language of the logic section of Avicenna's very important compendium al-Naj=at.

These parables balance three seemingly incompatible domains: creative collaboration within the limits of nature; catastrophic disaster tinged with the barest hint of human responsibility; and courageous, transforming coercion, the success of which renders an entire process vulnerable.

Caliphate in the light of theories of civilizations.

Bidirectional trans‐synaptic signaling is essential for the formation, maturation, and plasticity of synaptic connections. Synaptic cell adhesion molecules (CAMs) are prime drivers in shaping the identities of trans‐synaptic signaling pathways. A series of recent studies provide evidence that diverse presynaptic cell adhesion proteins dictate the regulation of specific synaptic properties in postsynaptic neurons. Focusing on mammalian synaptic CAMs, this article outlines several exemplary cases supporting this notion and highlights how these trans‐synaptic signaling pathways collectively contribute to the specificity and diversity (...) of neural circuit architecture. (shrink)